CTCAE Grade 3 Anus Stricture or Stenosis

Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Anus Pain

Severe pain; pain or analgesics severely interfering with ADL

CTCAE Grade 3 Anus Necrosis

Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated

CTCAE Grade 3 Anus Mucositis or Stomatitis by Functional or Symptomatic Classification

Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool…

CTCAE Grade 3 Anus Mucositis or Stomatitis by Clinical Examination Classification

Erythema of the mucosa

CTCAE Grade 3 Anus Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated

CTCAE Grade 3 Anus Hemorrhage

Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site)