CTCAE Grade 3 Bigeminy

Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator) (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Back Pain

Severe pain; pain or analgesics severely interfering with ADL

CTCAE Grade 3 Avascular Osteonecrosis

Symptomatic and interfering with ADL; operative intervention or hyperbaric oxygen indicated

CTCAE Grade 3 AV Block Third Degree

Incompletely controlled medically or controlled with device (e.g., pacemaker)

CTCAE Grade 3 AV Block Second Degree Mobitz Type II

Incompletely controlled medically or controlled with device (e.g., pacemaker)

CTCAE Grade 3 AV Block Second Degree Mobitz Type I

Incompletely controlled medically or controlled with device (e.g., pacemaker)

CTCAE Grade 3 AV Block First Degree

Incompletely controlled medically or controlled with device (e.g., pacemaker)