CTCAE Grade 3 Biliary Tree Fistula

Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Biliary Tree Common Hepatic Duct Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated

CTCAE Grade 3 Biliary Tree Common Bile Duct Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated

CTCAE Grade 3 Bigeminy

Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator)

CTCAE Grade 3 Back Pain

Severe pain; pain or analgesics severely interfering with ADL

CTCAE Grade 3 Avascular Osteonecrosis

Symptomatic and interfering with ADL; operative intervention or hyperbaric oxygen indicated

CTCAE Grade 3 AV Block Third Degree

Incompletely controlled medically or controlled with device (e.g., pacemaker)