CTCAE Grade 3 Bone Growth Limb Length Discrepancy

Severe length discrepancy >5 cm; operative intervention indicated; interfering with ADL (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Blurred Vision

Symptomatic and interfering with ADL

CTCAE Grade 3 Blood Infection with Unknown Absolute Neutrophil Count

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Blood Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Bladder Stricture or Stenosis

Symptomatic and altered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); operative intervention indicated

CTCAE Grade 3 Bladder Spasms