CTCAE Grade 3 Bone Marrow Cellularity

Severely hypocellular or >50 - <=75% reduction cellularity from normal for age (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Bone Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated

CTCAE Grade 3 Bone Infection with Unknown Absolute Neutrophil Count

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Bone Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Bone Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Bone Growth Limb Length Discrepancy

Severe length discrepancy >5 cm; operative intervention indicated; interfering with ADL

CTCAE Grade 3 Blurred Vision

Symptomatic and interfering with ADL