CTCAE Grade 3 Bronchus Fistula

Symptomatic and associated with altered respiratory function interfering with ADL; or endoscopic (e.g., stent) or primary closure by operative intervention indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Bronchospasm and Wheezing

Symptomatic interfering with function

CTCAE Grade 3 Bronchopulmonary Hemorrhage NOS

Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site)

CTCAE Grade 3 Breast Volume and Hypoplasia

Asymmetry exists, >1/3 of the breast volume; severe hypoplasia

CTCAE Grade 3 Breast Pain

Severe pain; pain or analgesics severely interfering with ADL

CTCAE Grade 3 Breast Nipple and Areolar Deformity

Marked deviation of nipple projection

CTCAE Grade 3 Breast Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated