CTCAE Grade 3 CNS Necrosis and Cystic Progression

Symptomatic, interfering with ADL (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 CNS Cerebrovascular Ischemia

Symptomatic, interfering with ADL

CTCAE Grade 3 Chylothorax

Operative intervention indicated

CTCAE Grade 3 Chyle or Lymph Leakage

Interventional radiology or operative intervention indicated

CTCAE Grade 3 Cholecystitis

Interventional radiology, endoscopic, or operative intervention indicated

CTCAE Grade 3 Chest Wall Pain

Severe pain; pain or analgesics severely interfering with ADL

CTCAE Grade 3 Chest and Thorax Pain

Severe pain; pain or analgesics severely interfering with ADL