CTCAE Grade 3 Colon Hemorrhage

Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Colitis

Abdominal pain, fever, change in bowel habits with ileus; peritoneal signs

CTCAE Grade 3 Cognitive Disturbance

Symptomatic, interfering with ADL

CTCAE Grade 3 CNS Necrosis and Cystic Progression

Symptomatic, interfering with ADL

CTCAE Grade 3 CNS Cerebrovascular Ischemia

Symptomatic, interfering with ADL

CTCAE Grade 3 Chylothorax

Operative intervention indicated

CTCAE Grade 3 Chyle or Lymph Leakage

Interventional radiology or operative intervention indicated