CTCAE Grade 3 Cytokine Release Syndrome or Acute Infusion Reaction

Prolonged (i.e., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for other clinical sequelae (e.g., renal impairment, pulmonary infiltrates) (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Cystitis

Transfusion; IV pain medications; bladder irrigation indicated

CTCAE Grade 3 Creatinine

3.0 - 6.0 x ULN

CTCAE Grade 3 Creatine Phosphokinase

5 x ULN - 10 x ULN

CTCAE Grade 3 Cranial Nerve XII Neuropathy

Symptomatic, interfering with ADL

CTCAE Grade 3 Cranial Nerve XII Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated

CTCAE Grade 3 Cranial Nerve XI Neuropathy

Symptomatic, interfering with ADL