CTCAE Grade 3 Diarrhea

Increase of >=7 stools per day over baseline; incontinence; IV fluids >=24 hrs; hospitalization; severe increase in ostomy output compared to baseline; interfering with ADL (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Depression

Severe mood alteration interfering with ADL

CTCAE Grade 3 Dental-Tooth Infection with Unknown Absolute Neutrophil Count

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Dental-Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Dental-Tooth Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Dental and Teeth and Peridontal Pain

Severe pain; pain or analgesics severely interfering with ADL

CTCAE Grade 3 Delayed Puberty

No sexual development by age 14 yrs for girls, age 16 yrs for boys; hormone replacement indicated