CTCAE Grade 3 Duodenum Fistula

Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Dry Skin

Interfering with ADL

CTCAE Grade 3 Dry Eye Syndrome

Symptomatic or decrease in visual acuity interfering with ADL; operative intervention indicated

CTCAE Grade 3 Dizziness

Interfering with ADL

CTCAE Grade 3 Disseminated Intravascular Coagulation

Laboratory findings and bleeding

CTCAE Grade 3 Diarrhea

Increase of >=7 stools per day over baseline; incontinence; IV fluids >=24 hrs; hospitalization; severe increase in ostomy output compared to baseline;…

CTCAE Grade 3 Depression

Severe mood alteration interfering with ADL