CTCAE Grade 3 Edema of the Limb

30% inter-limb discrepancy in volume; lymphorrhea; gross deviation from normal anatomic contour; interfering with ADL (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Edema of the Head and Neck

Generalized facial or neck edema with functional impairment (e.g., difficulty in turning neck or opening mouth compared to baseline)

CTCAE Grade 3 Dyspnea

Dyspnea with ADL

CTCAE Grade 3 Dysphagia

Symptomatic and severely altered eating/swallowing (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs …

CTCAE Grade 3 Duodenum Ulcer

Symptomatic and severely altered GI function (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs…

CTCAE Grade 3 Duodenum Stricture or Stenosis

Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated…

CTCAE Grade 3 Duodenum Perforation

IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated