CTCAE Grade 3 Edema of the Trunk and Genital Area

30% inter-limb discrepancy in volume; lymphorrhea; gross deviation from normal anatomic contour; interfering with ADL

Generalized facial or neck edema with functional impairment (e.g., difficulty in turning neck or opening mouth compared to baseline)

Dyspnea with ADL

Symptomatic and severely altered eating/swallowing (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs …

Symptomatic and severely altered GI function (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs…

Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated…