CTCAE Grade 3 Esophageal Varices Hemorrhage

Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Erectile Dysfunction

Decrease in erectile function (frequency/rigidity of erections) but erectile aids not helpful; penile prosthesis indicated

CTCAE Grade 3 Epiphora

Symptomatic, interfering with ADL

CTCAE Grade 3 Enteritis

Abdominal pain, fever, change in bowel habits with ileus; peritoneal signs

CTCAE Grade 3 Encephalopathy

Signs or symptoms interfering with ADL; hospitalization indicated

CTCAE Grade 3 Edema of the Viscera

Symptomatic and unable to aliment adequately orally; interventional radiology or operative intervention indicated

CTCAE Grade 3 Edema of the Trunk and Genital Area

Lymphorrhea; interfering with ADL; gross deviation from normal anatomic contour