CTCAE Grade 3 Extrapyramidal and Involuntary Movement and Restlessness

Severe involuntary movements or torticollis interfering with ADL (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Extraocular Muscle Weakness Not Due to Neuropathy

Symptomatic and interfering with ADL

CTCAE Grade 3 External Ear Pain

Severe pain; pain or analgesics severely interfering with ADL

CTCAE Grade 3 External Ear Infection with Unknown Absolute Neutrophil Count

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 External Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 External Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Exostosis