CTCAE Grade 3 Feminization of Male

Symptomatic interfering with ADL; invasive intervention indicated

Severe fatigue interfering with ADL

Symptomatic and altered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); operative intervention indicated

Symptomatic, operative intervention indicated

Symptomatic and altered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); operative intervention indicated