CTCAE Grade 3 Fibrosis-Deep Connective Tissue

Increased density with fixation of tissue; operative intervention indicated; interfering with ADL (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Fibrosis-Cosmesis

Significant disfigurement; operative intervention indicated if patient chooses

CTCAE Grade 3 Fibrinogen

<0.5 - 0.25 x LLN or 50 - <75% decrease from baseline

CTCAE Grade 3 Fever Without Neutropenia

40.0 degrees C (>104.0 degrees F) for <=24 hrs

CTCAE Grade 3 FEV1

<50 - 25% of predicted value

CTCAE Grade 3 Feminization of Male

CTCAE Grade 3 Female Genital Tract Fistula

Symptomatic interfering with ADL; invasive intervention indicated