CTCAE Grade 3 Heart Infection with Unknown Absolute Neutrophil Count

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Heart Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Hearing Patients without Baseline Audiogram and Not Enrolled in a Monitoring Program

Hearing loss requiring hearing aid or intervention (i.e., interfering with ADL)

CTCAE Grade 3 Hearing Patients with or without Baseline Audiogram and Enrolled in a Monitoring Program

Adult only: Threshold shift of >25 - 90 dB, averaged at 3 contiguous test frequencies in at least one ear Pediatric: Hearing…

CTCAE Grade 3 Head Soft Tissue Necrosis

Operative debridement or other invasive intervention indicated (e.g., hyperbaric oxygen)

CTCAE Grade 3 Head and Headache Pain

Severe pain; pain or analgesics severely interfering with ADL