CTCAE Grade 3 Hemorrhage and Bleeding Adverse Event Associated with Surgery

Requiring transfusion of 2 units non-autologous (10 cc/kg for pediatrics) pRBCs beyond protocol specification; postoperative interventional radiology, endoscopic, or operative intervention indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Hemolysis

Transfusion or medical intervention (e.g., steroids) indicated

CTCAE Grade 3 Hemoglobin

<8.0 - 6.5 g/dL <4.9 - 4.0 mmol/L <80 - 65 g/L

CTCAE Grade 3 Hematoma

Transfusion, interventional radiology, or operative intervention indicated

CTCAE Grade 3 Heartburn or Dyspepsia

CTCAE Grade 3 Heart Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated

CTCAE Grade 3 Heart Infection with Unknown Absolute Neutrophil Count

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated