CTCAE Grade 3 Hypotension

Sustained (>=24 hrs) therapy, resolves without persisting physiologic consequences (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Hypertension

Requiring more than one drug or more intensive therapy than previously Pediatric: Same as adult

CTCAE Grade 3 Hyperbilirubinemia

3.0 - 10.0 x ULN

CTCAE Grade 3 Hydrocephalus

Severe symptoms or neurological deficit interfering with ADL

CTCAE Grade 3 Hot Flashes or Flushes

Interfering with ADL

CTCAE Grade 3 Hiccoughs

Symptomatic, significantly interfering with sleep or ADL

CTCAE Grade 3 Hepatic Vein Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated