CTCAE Grade 3 Hypoxia

Decreased O(2) saturation at rest; continuous oxygen indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Hypothermia

32 - >28 degrees C 89.6 - >82.4 degrees F

CTCAE Grade 3 Hypotension

Sustained (>=24 hrs) therapy, resolves without persisting physiologic consequences

CTCAE Grade 3 Hypertension

Requiring more than one drug or more intensive therapy than previously Pediatric: Same as adult

CTCAE Grade 3 Hyperbilirubinemia

3.0 - 10.0 x ULN

CTCAE Grade 3 Hydrocephalus

Severe symptoms or neurological deficit interfering with ADL

CTCAE Grade 3 Hot Flashes or Flushes

Interfering with ADL