CTCAE Grade 3 Injection Site Reaction or Extravasation Changes

Ulceration or necrosis that is severe; operative intervention indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Infertility and Sterility

Male: sterile/azoospermia Female: infertile/anovulatory

CTCAE Grade 3 Inferior Vena Cava Vein Injury

Symptomatic interfering with ADL; repair or revision indicated

CTCAE Grade 3 Inferior Vena Cava Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated

CTCAE Grade 3 Infectious Colitis

IV antibiotics or TPN indicated

CTCAE Grade 3 Induration or Fibrosis of the Skin and Subcutaneous Tissue

Dysfunction interfering with ADL; very marked density, retraction or fixation

CTCAE Grade 3 Ileus

Symptomatic and severely altered GI function; IV fluids, tube feeding, or TPN indicated >24 hrs