CTCAE Grade 3 International Normalized Ratio of Prothrombin Time

2 x ULN (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Insomnia

Frequent difficulty sleeping, interfering with ADL

CTCAE Grade 3 Inner Ear Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated

CTCAE Grade 3 Injection Site Reaction or Extravasation Changes

Ulceration or necrosis that is severe; operative intervention indicated

CTCAE Grade 3 Infertility and Sterility

Male: sterile/azoospermia Female: infertile/anovulatory

CTCAE Grade 3 Inferior Vena Cava Vein Injury

Symptomatic interfering with ADL; repair or revision indicated

CTCAE Grade 3 Inferior Vena Cava Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated