CTCAE Grade 3 Irregular Menses

Persistent amenorrhea for >6 months (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Iron Overload

Iron overload, intervention indicated

CTCAE Grade 3 Intestine Pain

Severe pain; pain or analgesics severely interfering with ADL

CTCAE Grade 3 International Normalized Ratio of Prothrombin Time

CTCAE Grade 3 Insomnia

Frequent difficulty sleeping, interfering with ADL

CTCAE Grade 3 Inner Ear Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated

CTCAE Grade 3 Injection Site Reaction or Extravasation Changes

Ulceration or necrosis that is severe; operative intervention indicated