CTCAE Grade 3 Kidney Hemorrhage

Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Kidney Fistula

Symptomatic interfering with ADL; invasive intervention indicated

CTCAE Grade 3 Keratitis

Symptomatic and interfering with ADL; operative intervention indicated

CTCAE Grade 3 Jugular Vein Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated

CTCAE Grade 3 Jugular Vein Injury

Symptomatic interfering with ADL; repair or revision indicated

CTCAE Grade 3 Joint Pain

Severe pain; pain or analgesics severely interfering with ADL

CTCAE Grade 3 Joint Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated