CTCAE Grade 3 Left Ventricular Systolic Dysfunction

Symptomatic CHF responsive to intervention

Severe pain; pain or analgesics severely interfering with ADL

Interfering with ADL; stridor or endoscopic intervention indicated (e.g., stent, laser)

Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool…

Confluent ulcerations or pseudomembranes; bleeding with minor trauma

Complete resection or reconstruction of injured organ/structure indicated