CTCAE Grade 3 Local Complication of Device and Prosthesis

Symptomatic, interfering with ADL; operative intervention indicated (e.g., hardware/device replacement or removal, reconstruction) (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Liver Pain

Severe pain; pain or analgesics severely interfering with ADL

CTCAE Grade 3 Liver Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated

CTCAE Grade 3 Liver Infection with Unknown Absolute Neutrophil Count

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Liver Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Liver Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated

CTCAE Grade 3 Liver Hemorrhage

Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site)