CTCAE Grade 3 Lung Fistula

Symptomatic and associated with altered respiratory function interfering with ADL; or endoscopic (e.g., stent) or primary closure by operative intervention indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Lumbar Spine Range of Motion

Ankylosed/fused over multiple segments with no L-spine flexion (i.e., unable to reach to floor to pick up a very light object) …

CTCAE Grade 3 Lower Gastrointestinal Hemorrhage NOS

Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site)

CTCAE Grade 3 Lower Extremity Vein Intra-Operative Injury

Complete resection or reconstruction of injured organ/structure indicated

CTCAE Grade 3 Lower Extremity Vein Injury

Symptomatic interfering with ADL; repair or revision indicated

CTCAE Grade 3 Lower Extremity Soft Tissue Necrosis

Operative debridement or other invasive intervention indicated (e.g., hyperbaric oxygen)

CTCAE Grade 3 Lower Extremity Muscle Weakness Not Due to Neuropathy

Symptomatic and interfering with ADL