CTCAE Grade 3 Neuroendocrine ADH Secretion Abnormality

Symptoms interfering with ADL; hospitalization indicated

Severe pain; pain or analgesics severely interfering with ADL

Operative debridement or other invasive intervention indicated (e.g., hyperbaric oxygen)

Severe pain; pain or analgesics severely interfering with ADL

Complete resection or reconstruction of injured organ/structure indicated

IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated