CTCAE Grade 3 Neuroendocrine Prolactin Hormone Secretion Abnormality

Symptoms interfering with ADL; amenorrhea; galactorrhea (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Neuroendocrine Gonadotropin Secretion Abnormality

Symptoms interfering with ADL; osteopenia; fracture; infertility

CTCAE Grade 3 Neuroendocrine ADH Secretion Abnormality

Symptoms interfering with ADL

CTCAE Grade 3 Neuroendocrine ACTH Deficiency

Symptoms interfering with ADL; hospitalization indicated

CTCAE Grade 3 Neuralgia and Peripheral Nerve Pain

Severe pain; pain or analgesics severely interfering with ADL

CTCAE Grade 3 Neck Soft Tissue Necrosis

Operative debridement or other invasive intervention indicated (e.g., hyperbaric oxygen)

CTCAE Grade 3 Neck Pain

Severe pain; pain or analgesics severely interfering with ADL