CTCAE Grade 3 Nodal or Junctional Rhythm

Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) (NCI Thesaurus/CTCAE)

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CTCAE Grade 3 Neutrophils and Granulocytes

<1000 - 500/mm(3) <1.0 - 0.5 x 10e9 /L

CTCAE Grade 3 Neuroendocrine Prolactin Hormone Secretion Abnormality

Symptoms interfering with ADL; amenorrhea; galactorrhea

CTCAE Grade 3 Neuroendocrine Gonadotropin Secretion Abnormality

Symptoms interfering with ADL; osteopenia; fracture; infertility

CTCAE Grade 3 Neuroendocrine ADH Secretion Abnormality

Symptoms interfering with ADL

CTCAE Grade 3 Neuroendocrine ACTH Deficiency

Symptoms interfering with ADL; hospitalization indicated

CTCAE Grade 3 Neuralgia and Peripheral Nerve Pain

Severe pain; pain or analgesics severely interfering with ADL