CTCAE Grade 4 Jejunum Hemorrhage

Life-threatening consequences; major urgent intervention indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Iron Overload

Organ impairment (e.g., endocrinopathy, cardiopathy)

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CTCAE Grade 4 Inner Ear Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Inferior Vena Cava Vein Injury

Life-threatening; disabling; evidence of end organ damage