CTCAE Grade 4 Jugular Vein Injury

Life-threatening; disabling; evidence of end organ damage (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Joint Pain

CTCAE Grade 4 Joint Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Joint Infection with Unknown Absolute Neutrophil Count

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Joint Function

Fixed or non-functional joint (arthrodesis); >75% decrease in ROM