CTCAE Grade 4 Kidney Fistula

Life-threatening consequences; operative intervention requiring partial or full organ resection; permanent urinary diversion (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Keratitis

Perforation or blindness (20/200 or worse)

CTCAE Grade 4 Jugular Vein Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Jugular Vein Injury

Life-threatening; disabling; evidence of end organ damage

CTCAE Grade 4 Joint Pain

CTCAE Grade 4 Joint Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Joint Infection with Unknown Absolute Neutrophil Count

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)