CTCAE Grade 4 Large Bowel Mucositis or Stomatitis by Clinical Examination Classification

Tissue necrosis; significant spontaneous bleeding; life-threatening consequences (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Kidney Perforation

Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated

CTCAE Grade 4 Kidney Pain

CTCAE Grade 4 Kidney Leak

CTCAE Grade 4 Kidney Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Kidney Infection with Unknown Absolute Neutrophil Count

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)