CTCAE Grade 4 Laryngeal Nerve Dysfunction

Life-threatening; tracheostomy indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Large Bowel Mucositis or Stomatitis by Clinical Examination Classification

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CTCAE Grade 4 Kidney Perforation

Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated

CTCAE Grade 4 Kidney Pain

CTCAE Grade 4 Kidney Leak