CTCAE Grade 4 Larynx Fistula

Life-threatening consequences; operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Larynx Edema

Life-threatening airway compromise; tracheotomy, intubation, or laryngectomy indicated

CTCAE Grade 4 Laryngeal Nerve Dysfunction

Life-threatening; tracheostomy indicated

CTCAE Grade 4 Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification

Symptoms associated with life-threatening consequences

CTCAE Grade 4 Large Bowel Mucositis or Stomatitis by Clinical Examination Classification

Tissue necrosis; significant spontaneous bleeding; life-threatening consequences

CTCAE Grade 4 Large Bowel Leak

CTCAE Grade 4 Kidney Perforation

Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated