CTCAE Grade 4 Larynx Infection with Unknown Absolute Neutrophil Count

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Larynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Larynx Hemorrhage

Life-threatening consequences; major urgent intervention indicated

CTCAE Grade 4 Larynx Fistula

Life-threatening consequences; operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated

CTCAE Grade 4 Larynx Edema

Life-threatening airway compromise; tracheotomy, intubation, or laryngectomy indicated

CTCAE Grade 4 Laryngeal Nerve Dysfunction

Life-threatening; tracheostomy indicated