CTCAE Grade 4 Left Ventricular Systolic Dysfunction

Refractory CHF or poorly controlled; EF <20%; intervention such as ventricular assist device, ventricular reduction surgery, or heart transplant indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Left Ventricular Diastolic Dysfunction

Refractory CHF, poorly controlled; intervention such as ventricular assist device or heart transplant indicated

CTCAE Grade 4 Larynx Pain

CTCAE Grade 4 Larynx Obstruction and Stenosis

Life-threatening airway compromise; tracheotomy or intubation indicated

CTCAE Grade 4 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification

Symptoms associated with life-threatening consequences

CTCAE Grade 4 Larynx Mucositis or Stomatitis by Clinical Examination Classification

Tissue necrosis; significant spontaneous bleeding; life-threatening consequences

CTCAE Grade 4 Larynx Intra-Operative Injury

Life threatening consequences; disabling