CTCAE Grade 4 Liver Hemorrhage

Life-threatening consequences; major urgent intervention indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Liver Dysfunction or Failure by Clinical Classification

Encephalopathy or coma

CTCAE Grade 4 Lipase

CTCAE Grade 4 Lip Pain

CTCAE Grade 4 Lip or Perioral Infection with Unknown Absolute Neutrophil Count

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Lip or Perioral Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)