CTCAE Grade 4 Lower Extremity Artery Injury

Life-threatening; disabling; evidence of end organ damage (e.g., stroke, MI, organ or limb loss) (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Low Serum Bicarbonate

<8 mmol/L

CTCAE Grade 4 Local Complication of Device and Prosthesis

Life-threatening; disabling; loss of limb or organ

CTCAE Grade 4 Liver Pain

CTCAE Grade 4 Liver Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Liver Infection with Unknown Absolute Neutrophil Count

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Liver Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)