CTCAE Grade 4 Lower Extremity Soft Tissue Necrosis

Life-threatening consequences; major invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting) (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Lower Extremity Muscle Weakness Not Due to Neuropathy

CTCAE Grade 4 Lower Extremity Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Lower Extremity Gait

Unable to walk

CTCAE Grade 4 Lower Extremity Artery Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Lower Extremity Artery Injury

Life-threatening; disabling; evidence of end organ damage (e.g., stroke, MI, organ or limb loss)

CTCAE Grade 4 Low Serum Bicarbonate

<8 mmol/L