CTCAE Grade 4 Metabolic or Respiratory Acidosis

pH <7.3 with life-threatening consequences (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Meninges Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Meninges Infection with Unknown Absolute Neutrophil Count

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Memory Impairment

CTCAE Grade 4 Mediastinum Intra-Operative Injury

Life threatening consequences; disabling