CTCAE Grade 4 Nasal Cavity and Paranasal Sinus Reactions

Necrosis of soft tissue or bone (NCI Thesaurus/CTCAE)

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Life threatening consequences; disabling

CTCAE Grade 4 Myositis

CTCAE Grade 4 Myocarditis

Severe or refractory CHF

CTCAE Grade 4 Myelodysplasia

RAEB or RAEB-T (marrow blasts >5%)

CTCAE Grade 4 Myelitis

CTCAE Grade 4 Muscular and Skeletal Hypoplasia