CTCAE Grade 4 Non-Infectious Wound Complication

Symptomatic hernia with evidence of strangulation; fascial disruption with evisceration; major reconstruction flap, grafting, resection, or amputation indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Non-Fatal Cardiopulmonary Arrest Cause Unknown

CTCAE Grade 4 Nodal or Junctional Rhythm

Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)

CTCAE Grade 4 Neutrophils and Granulocytes

<500/mm(3) <0.5 x 10e9 /L

CTCAE Grade 4 Neuroendocrine ADH Secretion Abnormality

CTCAE Grade 4 Neuroendocrine ACTH Deficiency

Life-threatening consequences (e.g., severe hypotension)

CTCAE Grade 4 Neuralgia and Peripheral Nerve Pain