CTCAE Grade 4 Non-Malignant Pleural Effusion

Life-threatening consequences (e.g., tamponade); emergency intervention indicated

Symptomatic hernia with evidence of strangulation; fascial disruption with evisceration; major reconstruction flap, grafting, resection, or amputation indicated

Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)

<500/mm(3) <0.5 x 10e9 /L