CTCAE Grade 4 Nose Hemorrhage

Life-threatening; disabling; evidence of end organ damage

Life-threatening (e.g., causing hemodynamic instability or ventilatory support indicated)

Life-threatening consequences (e.g., tamponade); emergency intervention indicated

Symptomatic hernia with evidence of strangulation; fascial disruption with evisceration; major reconstruction flap, grafting, resection, or amputation indicated