CTCAE Grade 4 Other Pulmonary and Upper Respiratory

Life-threatening; disabling (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Other Pain

CTCAE Grade 4 Other Ocular and Visual

Blindness (20/200 or worse)

CTCAE Grade 4 Other NOS Vein Injury

Life-threatening; disabling; evidence of end organ damage

CTCAE Grade 4 Other NOS Artery Injury

Life-threatening; disabling; evidence of end organ damage (e.g., stroke, MI, organ or limb loss)

CTCAE Grade 4 Other Neurology

CTCAE Grade 4 Other Musculoskeletal and Soft Tissue