CTCAE Grade 4 Prostate Obstruction

Life-threatening consequences; organ failure or operative intervention requiring complete organ resection indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Prostate Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Prostate Infection with Unknown Absolute Neutrophil Count

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Prostate Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Prostate Hemorrhage

Life-threatening consequences; major urgent intervention indicated

CTCAE Grade 4 Prolonged QTc Interval

QTc >0.50 second; life-threatening signs or symptoms (e.g., arrhythmia, CHF, hypotension, shock syncope); Torsade de pointes