CTCAE Grade 4 Serum Hyperglycemia

500 mg/dL >12.92 mmol/L

13.5 mg/dL >3.4 mmol/L Ionized calcium >1.8 mmol/L

Seizures of any kind which are prolonged, repetitive, or difficult to control (e.g., status epilepticus, intractable epilepsy)